This paper is of particular interest to crunchers. (12 minute read) Notice the contributions by Baker Labs (Rosetta)
https://www.nature.com/articles/d41586-021-03499-y?utm_source=Nature+Briefing&utm_campaign=07ae2d7007-briefing-dy-20211123&utm_medium=email&utm_term=0_c9dfd39373-07ae2d7007-45627838
See also the post at Rosetta:
https://boinc.bakerlab.org/rosetta/forum_thread.php?id=8439#83045