Project Update

[Dingo]

[SIDock@home] Project status: December 2023
Dear SiDock@home participants,

We've successfully achieved 21 milestones in our ongoing drug discovery initiative, and this strong, open, and community-supported drug discovery project is going on. Our research has been routine lately: virtual screening on the same library for a pleiade of corona-related targets. These efforts are however crucial to our research progression. Currently, we're in the process of drafting publications for two of our completed objectives (3CLpro and PLpro) and are setting the stage for upcoming drug targets (here we are also planning a pool where You the participants, will help us decide on the upcoming target work).
Last but not least, we thank everyone who has donated cryptocurrency or money. The donations sum up to 639 Euro and 12,140 Gridcoin now. We plan to use them for purchase of compounds and in-vitro screening. As always, we are grateful to all of you for your computational contributions and discussions!

We look forward to the future work on SiDock@home.

Merry Christmas to all and all the best to All!

With best wishes,
Natalia, Marko, Črtomir and hoarfrost

View article· Tue, 26 Dec 2023 19:37:17 +0000

[Abruraspingi]

That is cool. I'd love to see more of this

[Dingo]

[SIDock@home] Vote for the next target!

Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024.

SARS-CoV-2 main protease (3CLpro) further studies

This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors.

Ebolavirus glycoprotein (GP)

Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.

Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)

This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.
View article · Fri, 26 Jan 2024 12:36:20 +0000