News:

If you are a member of the Team on BOINC you still need to register on this forum to see the member posts.  The posts available for visitors are not posted to much by members.
 Remember to answer the questions when Registering and also you must be a active member of Team BOINC@AUSTRALIA on BOINC.

Main Menu

Project Overview

Started by Cruncher Pete, May 18, 2009, 08:37:46 PM

Previous topic - Next topic

Cruncher Pete

   




Project Summary
The amino acid sequence of a protein determines its three-dimensional structure, or 'fold'. Conversely, the three-dimensional structure is compatible with a large, but limited set of amino acid sequences. Enumerating the allowed sequences for a given fold is known as the 'inverse protein folding problem'. We are working to solve this problem for a large number of known protein folds (a representative subset: about 1500 folds). The most expensive step is to build a database of energy functions that describe all these structures. For each structure, we consider all possible sequences of amino acids. Surprisingly, this is computationally tractable, because our energy functions are sums over pairs of interactions. Once this is done, we can explore the space of amino acid sequences in a fast and efficient way, and retain the most favorable sequences. This large-scale mapping of protein sequence space will have applications for predicting protein structure and function, for understanding protein evolution, and for designing new proteins. By joining the project, you will help to build the database of energy functions and advance an important area of science with potential biomedical applications.

Applications
The following applications are supported:

Microsoft Windows X86  (32bit)

Connecting to Proteins@Home
The project's Home Page is located at: http://biology.polytechnique.fr/proteinsathome/
Proteins@Home is also listed in the various BOINC Account Managers and you can join this project through them directly.
Don't forget to join BOINC@Australia following your registration.

Statistics
View our Team Members List and their current score here
View detailed BOINCStats for our Team here